Abstract: Retinopathy of prematurity (ROP) has already become the leading cause of blindness in children worldwide, while neovascularization is the significant pathological cause of ROP occurrence and development. Except for participating in coagulation and hemostasis, wound healing, inflammation and tumor metastasis, platelets, the cellular debris produced by mature macrophages, play an important role in angiogenesis through regulating angiogenesis related factors and cells. Researchers have shown that the role and variation of platelets in ROP may provide new ideas for early screening and treatment with platelets infusion.

Key words: retinopathy of prematurity, platelets, angiogenesis